Sodium Saccharin is an artificial sweetener that is commonly used as a sugar substitute. It is 300-400 times sweeter than sugar and has no calories, making it a popular choice for those on low-calorie diets. However, it has been linked to potential health risks and controversy surrounds its safety.
| IUPAC Name | Sodium 1,2-benzisothiazol-3(2H)-one 1,1-dioxide |
| Molecular Formula | C7H4NNaO3S |
| CAS Number | 128-44-9 |
| Synonyms | Acid saccharin; Anhydrous saccharin; Sodium o-benzosulfimide; Benzoic acid, 2-sulfamoyl-, sodium salt; Natriumsaccharin; Saccharin sodium; Sodium ortho-sulfobenzimide; INS No. 954 |
| InChI | InChI=1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)13(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1 |
Sodium Saccharin Formula
The chemical formula of Sodium Saccharin is C7H4NNaO3S. This formula represents the number and type of atoms in a molecule of Sodium Saccharin. The formula can be used to calculate various properties of Sodium Saccharin, including molar mass, molecular weight, and stoichiometry in chemical reactions.
Sodium Saccharin Melting Point
Sodium Saccharin has a melting point of 226-230°C (439-446°F). This high melting point is due to the strong intermolecular forces that exist between the molecules of sodium ortho-sulfobenzimide. As the temperature increases, the intermolecular forces weaken, and the molecules start to move more freely, leading to a liquid state. At the melting point, the intermolecular forces are just strong enough to hold the molecules together in a solid state, but any further heating causes the molecules to separate into a liquid state.
Sodium Saccharin Molar Mass
Sodium Saccharin has a molar mass of 205.17 g/mol. It is a small molecule that consists of carbon, nitrogen, oxygen, sulfur, and sodium atoms. The molar mass of a compound is the sum of the atomic masses of all the atoms in the molecule. The knowledge of the molar mass of sodium ortho-sulfobenzimide is important in many chemical calculations, including the preparation of solutions and the determination of stoichiometry in chemical reactions.
Sodium Saccharin Boiling Point
Sodium Saccharin has a relatively high boiling point of 438.9°C (821.8°F). This temperature is well above the boiling point of water, which makes sodium ortho-sulfobenzimide stable at high temperatures. The high boiling point is due to the strong hydrogen bonds that form between the molecules of sodium ortho-sulfobenzimide. At high temperatures, these bonds must be broken before the molecules can become gaseous. This property makes sodium ortho-sulfobenzimide useful in a variety of industrial applications that require high-temperature stability.
Sodium Saccharin Density g/ml
The density of Sodium Saccharin is approximately 0.76 g/mL at room temperature. Density is a physical property that measures the mass of a substance per unit volume. The density of a substance can vary with temperature, pressure, and other environmental conditions. The knowledge of the density of sodium ortho-sulfobenzimide is important in various applications, including the formulation of solutions and determining the amount of sodium ortho-sulfobenzimide needed to achieve a certain concentration.
Sodium Saccharin Structure
Sodium Saccharin has a complex structure consisting of a fused ring system containing carbon, nitrogen, sulfur, and oxygen atoms. The molecule has a nitrogen atom that is double-bonded to one of the carbon atoms, which is part of the fused ring system. This double bond imparts a unique chemical property to sodium ortho-sulfobenzimide, making it a useful chemical compound for a variety of applications.
Sodium Saccharin Molecular Weight
The molecular weight of Sodium Saccharin is 205.17 g/mol. The molecular weight is the sum of the atomic weights of all the atoms in a molecule. The knowledge of the molecular weight of sodium ortho-sulfobenzimide is important in various chemical calculations, including determining the amount of sodium ortho-sulfobenzimide required for a specific reaction, and the conversion of mass to moles and vice versa.
| Appearance | White crystalline powder |
| Specific Gravity | 0.76 g/mL at 20°C |
| Color | White |
| Odor | Odorless |
| Molar Mass | 205.17 g/mol |
| Density | 0.76 g/mL at 20°C |
| Melting Point | 226-230°C (439-446°F) |
| Boiling Point | 438.9°C (821.8°F) |
| Flash Point | Not applicable |
| Water Solubility | 2.7 g/L at 20°C (pH 7) |
| Solubility | Soluble in ethanol and acetone |
| Vapour Pressure | Not applicable |
| Vapour Density | Not applicable |
| pKa | 2.2-2.4 (at 25°C) |
| pH | 4.5-5.5 (1% solution at 25°C) |
Sodium Saccharin Safety and Hazards
Saccharin sodium or sodium ortho-sulfobenzimide is generally considered safe for human consumption in moderate amounts. However, it may cause allergic reactions in some individuals, such as skin rashes or difficulty breathing. Additionally, long-term consumption of high doses of sodium ortho-sulfobenzimide may increase the risk of bladder cancer. It is important to follow the recommended daily intake and consult with a healthcare professional before consuming sodium ortho-sulfobenzimide, particularly if you have a history of allergies or bladder cancer. sodium ortho-sulfobenzimide is not considered a hazardous substance, but it should be handled with care and kept away from open flames or heat sources.
| Hazard Symbols | None |
| Safety Description | Harmful if swallowed. |
| UN Ids | Not applicable |
| HS Code | 292511 |
| Hazard Class | Not classified as hazardous according to GHS |
| Packing Group | Not applicable |
| Toxicity | Low toxicity |
Sodium Saccharin Synthesis Methods
Saccharin sodium is commonly synthesized through the oxidation of o-toluenesulfonamide. The reaction is typically carried out using a mixture of nitric acid and sulfuric acid as the oxidizing agent. The resulting product is then neutralized with sodium hydroxide to form sodium ortho-sulfobenzimide.
Another method involves the reaction of anthranilic acid with chlorosulfonic acid, followed by treatment with ammonia to produce 1,2-benzisothiazolin-3-one. The benzisothiazolinone is then further reacted with sodium hydroxide to yield sodium ortho-sulfobenzimide.
A third method involves the reaction of phthalic anhydride with ammonia and sulfur dioxide to form phthalimide-2-sulfonamide. The phthalimide derivative is then treated with sodium hydroxide to produce sodium ortho-sulfobenzimide.
Sodium Saccharin Uses
- The food and beverage industry commonly uses sodium ortho-sulfobenzimide as a sweetener, which provides a sugar-like taste without adding calories. This is beneficial for people with diabetes or those who want to reduce their sugar intake.
- Sodium ortho-sulfobenzimide is also used in the production of pharmaceuticals, including cough syrups and toothpaste.
- The oil and gas industry utilizes sodium ortho-sulfobenzimide as a corrosion inhibitor, which helps protect equipment from degradation and extends its lifespan.
- Sodium ortho-sulfobenzimide is used as a dye intermediate and as a preservative in cosmetics and personal care products.
- Researchers have studied sodium ortho-sulfobenzimide for its potential therapeutic applications. It has shown promise as a treatment for certain types of cancer, including lung and colon cancer. Additionally, it may have antioxidant and anti-inflammatory properties.
Overall, sodium ortho-sulfobenzimide has a wide range of applications across various industries, and its versatility and low cost make it a popular choice for manufacturers. However, it is important to use sodium ortho-sulfobenzimide in moderation and follow appropriate safety guidelines to ensure its safe use.
Questions:
Is sodium saccharin safe?
Saccharin sodium is generally considered safe for human consumption in moderate amounts. The US FDA has classified sodium ortho-sulfobenzimide as a Generally Recognized as Safe (GRAS) food additive, and it is approved for use in a variety of food and beverage products. However, long-term consumption of high doses of sodium ortho-sulfobenzimide may increase the risk of bladder cancer. It is important to follow the recommended daily intake and consult with a healthcare professional before consuming sodium ortho-sulfobenzimide, particularly if you have a history of allergies or bladder cancer.
In addition, some individuals may experience allergic reactions to sodium ortho-sulfobenzimide, such as skin rashes or difficulty breathing. Therefore, it is important to use sodium ortho-sulfobenzimide in moderation and follow appropriate safety guidelines to minimize any potential risks. Overall, when used as directed, sodium ortho-sulfobenzimide is considered a safe and effective sugar substitute and is widely used in various food and beverage products.
Sodium saccharin in mouthwash?
Saccharin sodium is commonly used as a sweetener in mouthwash products, providing a sugar-like taste without contributing to tooth decay. Additionally, sodium ortho-sulfobenzimide can improve the overall mouthfeel of mouthwash products, making them more palatable and enjoyable to use.
However, it is important to note that some individuals may have allergies or sensitivities to sodium ortho-sulfobenzimide, which can cause adverse reactions such as skin irritation or difficulty breathing. In addition, long-term exposure to high levels of sodium ortho-sulfobenzimide has been linked to an increased risk of bladder cancer. Therefore, it is important to use mouthwash products containing sodium ortho-sulfobenzimide in moderation and follow appropriate safety guidelines to minimize any potential risks.